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Gene name:
ICAM1;
Protein name:
Intercellular adhesion molecule 1(ICAM-1);
Alternative:
CD:
CD54;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF.
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Subcellular Location:
Membrane Single-pass type I membrane protein
Protein Attributes:
Sequence length:
535
Sequence:
50:
MALGAAPAAQ | LALLALLGTL | LPGPGGAGIS | IHPSKAIIPR | GDSLTVNCSN |
100:
SCDQKSTFGL | ETVLIKEEVG | RGDNWKVFQL | RDVQEDIELF | CYSNCHKEQT |
150:
IASMNLTVYW | FPEHVELAPL | PLWQPVGEEL | NLSCLVSGGA | PRAHLSVVLL |
200:
RGEEELGRQP | VGKGEPAKVM | FTVQSRREDH | GTNFSCRWEL | DLRSQGLELF |
250:
QNTSAPRKLQ | TYVLPSIDPH | LEVPPIVEVG | SRWPVNCTLD | GLFPASDAKV |
300:
YLVLGDQKLE | SNITYDGDSV | LAKAWMEENE | EGTHSLKCSV | TLGEVSRRTQ |
350:
ENVTVYSFPL | PTLTLSPPEV | SEWTTVTVEC | VTRDGAVVKL | NGTSAVPPGP |
400:
RAQLKLNASA | SDHRSNFSCS | AALEIAGQVV | HKHQTLELHV | LYGPRLDQRD |
450:
CPGNWTWQEG
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